The 5α-Androstanedione Pathway to Dihydrotestosterone in Castration-Resistant Prostate Cancer
نویسندگان
چکیده
منابع مشابه
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer.
In the majority of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal testosterone. The response is usually transient, and metastatic tumors almost invariably eventually progress as castration-resistant prostate cancer (CRPC). The development of CRPC is dependent upon the intratumoral generation of the potent androgen, dihydrotestosterone ...
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Physiologically relevant steroid 5α-reductase (SRD5A) activity that is essential for dihydrotestosterone (DHT) biosynthesis in human castration-resistant prostate cancer (CRPC) has not been fully characterized yet. In this study to ascertain the potential SRD5A activity, we cultured two human CRPC cell lines, C4-2 and C4-2AT6, with the steroid precursor: ¹³C-[2,3,4]-androstenedione (13C-Adione)...
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ژورنال
عنوان ژورنال: Journal of Investigative Medicine
سال: 2012
ISSN: 1081-5589,1708-8267
DOI: 10.2310/jim.0b013e31823874a4